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The present study aimed to examine the effectiveness of integrative family therapy (cognitive-behavioral and emotion-focused) on improving metacognitions and reducing depression in couples. This study employed a quasi-experimental pretest–posttest design with a control group and was applied in nature. The statistical population consisted of couples who referred to the Andisheh Sabz Counseling Center in Qom in 2025 to receive treatment for depression and to improve their metacognitive skills. The sample was selected using available and purposive sampling methods. Based on Krejcie and Morgan’s formula, a total of 30 participants (15 in the experimental group and 15 in the control group) were selected. Data were collected using the Beck Depression Inventory (BDI) and the Metacognitions Questionnaire developed by Wells and Cartwright-Hatton (1997). The integrative family therapy intervention was implemented using protocols from cognitive-behavioral family therapy and emotion-focused family therapy during a series of structured sessions. Data were analyzed using appropriate statistical methods, including analysis of covariance (ANCOVA). The results indicated that integrative family therapy significantly reduced depression and improved metacognitions in the experimental group compared to the control group.