Multiple Sclerosis (MS) is a progressive neurological disease that affects many people, especially young women. Patients with MS experience psychological problems. The aim of this study was to compare the social well-being, spiritual well-being and emotion regulation strategies in multiple Sclerosis (MS) patients and non-patients. In this causal-comparison research, the statistical population consisted of 700 patients with MS in Kermanshah. Among the population, 149 patients were selected by convenience sampling method. Among non- patients, 149 people were matched in age and gender with the patients group. Data were collected using the Social well-being, Spiritual well-Being and Emotion Regulation Scales. The results of two-way Multivariate Analysis of Variance showed that the spiritual health and its components (religious and existential well-being), social well-being and its three dimensions (social flourishing, social acceptance, and social adaptation) and emotional reappraisal in patients with MS were lower than non-patients. But there was no significant difference between the emotional suppression in two groups. The results have important implications in attending to the terms of social well-being, spiritual well-being and emotion regulation strategies in patients with MS. Based on the results, improving social and spiritual well-being and increasing the patient's emotion regulation strategies are recommended through spiritual and social health education and training the emotion regulation strategies.