Purpose: there are several factors which mentioned in sexual health. In overall, biological, psychological and cultural factors effect on sexual health. The aim of this study was the investigation of predictive role of biological and psychological factors with the mediator role of cultural factors in sexual health. In this regard, direct and indirect effects of these variables were investigated  to predict sexual health.

Method: the instruments of this study included ENRICH marital satisfaction questionnaire, Beck self-concept scale, Bem's gender schemas questionnaire, Sherer's self-efficacy questionnaire, Amz's Narcissistic personality inventory,  quality of object relations inventory,Brief Index of Sexual Functioning for Women (BISF-W), and checklist of menopause symptoms, which performed on 307 women in Tehran between 1393-1394.

Findings: results suggest that cultural factors effect directly on sexual health. In addition, biological and psychological predict sexual health in direct and indirect (with the mediator role of cultural factors) way.

Conclusion: results show that this model is acceptable for explaining sexual health in menopausal women.